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KMID : 0371320100780060385
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Journal of the Korean Surgical Society
2010 Volume.78 No. 6 p.385 ~ p.389
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예방적 항생제; 단일요법; 복강경 결장직장수술; 수술부위감염; 병원감염
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Kwak Han-Deok
Um Jun-Won
Kim Seon-Hahn
Kim Jin
Choi Dong-Jin
Woo Si-Uk
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Abstract
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Purpose: We performed this study to compare 1-day group using a 2nd generation cephalsporin with 3-day group for evaluating hospital acquired infection.
Methods: The patients underwent laparoscopic colorectal surgery at Korea University Medical Center Anam Hospital, from August, 2007 to June, 2008. They were randomly allocated to 2 groups: 1-day or 3-day group. A 2nd generation cephalosporin was administered within 1 hour before surgery with 12-hour intervals. In cases of suspected infection, further studies were done to identify infection.
Results: The study included 154 patients (1-day group - 78, vs. 3-day group - 76). No differences were noted between the 2 groups in age, body mass index, smoking, diabetes mellitus, corticosteroid-use were noted. Gender (P=0.011) and mean operative time (P=0.047) between the 2 groups were different. The preventive rates of infection were 87.18% in the 1-day group compared with 82.89% in the 3-day group (P=0.456).
Conclusion: Our prospective randomized control study concluded that there were no differences between the 1-day and 3-day group in hospital acquired infection. We could come to the conclusion that 1-day antimicrobial agent in laparoscopic colorectal surgery would be adequate in preventing infection.
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KEYWORD
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Antimicrobial prophylaxis, Monotherapy, Laparoscopic colorectal surgery, Surgical site infection, Hospital acquired infection
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